One of the most important concerns many have with taking CBD is how it will interact with other drugs.
Most substances will interact in some way or another if taken with other substances. You may have noticed that many prescription drugs will advise you to avoid grapefruit when taking them because it can affect how the body metabolizes the drug.
Of course the quality of the CBD product also matters and it's always good to make sure that if you do take CBD that you should take quality lab tested product.
CBD affects the endocannabinoid system and inhibits the activity of cytochrome p450.
Cytochrome p450 is a group of enzymes found in the liver that are responsible for breaking down substances that enter the body. Since CBD inhibits the activity of this enzyme it can momentarily deactivate it's activity which can effect how other compounds are metabolized.
Grapefruit juice also inhibits the cytochrome p450 enzymes. Since both grapefruit juice and CBD can inhibit the same enzyme any drug that is advised not to be consumed alongside grapefruit juice should not be consumed with CBD.
A list of drugs that shouldn't be taken alongside grapefruit juice can be found on drugs.com
- aliskiren (Tekturna)
- alprazolam (Xanax)
- amiodarone (Pacerone)
- atorvastatin (Lipitor)
- carbamazepine (Tegretol)
- cilostazol (Pletal)
- clarithromycin (Biaxin)
- cyclosporine (Gengraf, Neoral)
- dronedarone (Multaq)
- erythromycin (E.E.S., Eryped)
- felodipine (Plendil)
- fentanyl transdermal system (Duragesic Skin Patch)
- fexofenadine (Allegra)
- flibanserin (Addyi)
- indinavir (Crixivan)
- loratadine (Claritin)
- losartan (Cozaar)
- nilotinib (Tasigna)
- naloxegol (Movantik)
- palbociclib (Ibrance)
- pazopanib (Votrient)
- pimozide (Orap)
- ranolazine (Ranexa)
- saquinavir (Invirase, Fortovase)
- sildenafil (Revatio, Viagra)
- simvastatin (Zocor)
- tadalafil (Adcirca, Cialis)
- vardenafil (Levitra, Staxyn)
- verapamil (Calan, Calan SR)
These are just the most common ones known and won't list all of the ones that can interact with grapefruit juice. Make sure to consult with a doctor before taking CBD if you're currently using any medications.
Studies have shown that CBD and other cannabinoids can increase the effects of blood thinners or drugs with a risk of blood thinning.
CBD can induce sedative effects on the user in higher concentrations. Since this is the case when combined with sedatives CBD can intensify the sedative nature of those drugs.
Although CBD has shown to help some with epileptic seizures CBD could cause problems when taken alongside anti-seizure medication.
A 1992 study showed that low doses of CBD does not cause anti-epileptic effects but can still inhibit cytochrome p450 and result in higher concentrations of clobazam and norclobazam which could actually result in more aggressive seizures.
Interaction with Chemo drugs
Many Chemotherapy drugs need to be metabolized at a certain rate while entering the body. Since this is the case CBD can end up inhibiting the breakdown of the chemotherapy drugs and result in higher concentrations of the drug in the bloodstream.
Although this has been stated it needs to be understood that you should ask a health professional before taking CBD alongside any other medication.
Source - CBD origin: https://medium.com/cbd-origin/is-it-safe-to-take-c...